Polymyalgia rheumatica (PMR) is an inflammatory condition that causes widespread joint and muscle pain along with stiffness, especially in the shoulders and hips. Symptoms often affect both sides of the body and can appear sudden or develop over several days to weeks. It mostly affects adults over age 50 and is more common in people over 65. Corticosteroids such as prednisone have been the standard treatment for PMR, but despite their use, many patients flare while tapering, relapse after discontinuation, or require long-term steroid use. Long-term exposure to corticosteroids increases the risk of weight gain, diabetes, high blood pressure, weakening of bones and fractures, cataracts, and more.
Kevzara (sarilumab) is a biologic medication that has commonly been prescribed by rheumatologists for moderate to severe rheumatoid arthritis. Recently, Kevzara has also been approved for use in adults with PMR, who have had a poor response to prednisone or for whom prednisone cannot be tapered without having a flare. Using Kevzara will allow for tapering of prednisone over a shorter period of time with a reduced chance of flares.
If you are a patient with PMR, Kevzara could be a treatment to consider with your rheumatologist. Charlton Health is pleased to support patients using biologic treatments for many immune-mediated conditions.
Parvinder Sahota is a clinical pharmacist and a graduate from the University of Toronto. He enjoys learning about the ever-evolving field of autoimmune conditions and their treatment options.