Looking back: Is Folic Acid Needed With Methotrexate?

This week on our #WiseWordsWednesday blog we’re continuing to look back at some of our most popular blogs. Today, we’re focusing on our blog about taking folic acid alongside methotrexate. This continues to be a question we get all the time, so we thought we would share it with you today!
Here is the original post…

Is Folic Acid Needed With Methotrexate?

Methotrexate is a medication used in low weekly doses in the treatment of many autoimmune conditions, from rheumatoid arthritis to psoriasis to inflammatory bowel disease.  One way methotrexate works is by decreasing the production of folate.  For this reason, folic acid supplementation is used to offset possible adverse effects.  If too much folic acid is taken, it could decrease the effectiveness of methotrexate and if not enough is taken, there is a greater chance of nausea, mouth ulcers and changes in liver function tests. The amount suggested ranges from 5 mg a week up to 5mg everyday except the day methotrexate is taken. 

If you are experiencing adverse effects from methotrexate and are taking a low dose, you may wish to speak to your specialist about the way you take folic acid.  Another option is to use the prescription medication folinic acid instead of folic acid.  It is the “activated” form of folic acid and is more costly.  As up to 20% of patients cannot process folic acid into the active form, folinic acid can be a good alternative.  In people who make this conversion, folinic acid doesn’t offer better protection against adverse effects but in others it could make a difference.  It is generally taken as 5mg once weekly.

Stay tuned for next week’s blog when more strategies for reducing potential fatigue from methotrexate will be discussed…


Carolyn Whiskin is the Pharmacy Manager for Charlton Health.  Carolyn specializes in the treatment of autoimmune diseases, pharmaceutical compounding, women’s health, pain and smoking cessation. Carolyn has won provincial and national awards for her commitment to patient care and public service.

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Looking Back: Which foods are inflammatory?

As we’ve been doing over the past few weeks, today for our #WiseWordsWednesday blog, we’re looking back at some of our more popular blogs from over the years. As the seasons change and we start to eat higher amounts of comfort foods, we thought it would be a great time to look back at which foods are found to be inflammatory. Inflammatory foods can sometimes impact those that live with inflammation-based illnesses, such as arthritis.

 

Here is the text of the original article:

As health professionals, we are often asked about the role inflammatory foods play in reducing inflammation throughout the body.  The natural body fluids in a healthy person are alkaline (high pH) and are found to be more acidic in those who are ill (low pH). The pH scale is from 1 to 14, with 7 being considered neutral.  Numbers above 7 are considered acidic and numbers below 7 are referred to as alkaline.

Some people who have chosen foods in their diet which are not acidic have noticed a difference in their pain, while others have not found a difference.

Foods that have the greatest acidity include: soybean, hazelnuts, walnuts, brazil nuts, barley, beef, lobster, processed cheese, ice cream, beer, sugar, cocoa and white vinegar. Foods that are the least acidic (alkaline) include lime, nectarines, raspberries, watermelon, lentils, yams, onion and pumpkin seeds.  For those interested in seeing a chart of these foods, Charlton Health is happy provide one to you.

Keep in mind this does not replace researched treatments and may not be effective for everyone.  Reducing sugar intake and eating a well balanced diet with omega-3 fish oil and limited processed foods is always suggested.

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Osteoporosis Specific Exercise Program

Bonefit is a program that was designed by health professionals in cooperation with the Osteoporosis Society to “reduce fractures, morbidity, mortality and costs from osteoporosis through an integrated and comprehensive approach aimed at health promotion and disease management.”1 The program has three self directed modules and a workshop component. Specialists in rehabilitation medicine must complete a certification course to be instructors. The Bonefit website lists where instructors can be found anywhere in Canada. There are several in southern Ontario in a range of settings, from private clinics to the YMCA.

Learn more about this program by contacting:
Phone: 416-696-2663 ext. 2290
Email: bonefit@osteoporosis.ca

Maintaining the goal of 150 minutes of exercise per week is important for all Canadians. However, doing it in a way that is safe and offers your the most benefit is important. Using this resource can help you make sure any exercise you’re doing is done safely.


Carolyn Whiskin is the Pharmacy Manager for Charlton Health.  Carolyn specializes in the treatment of autoimmune diseases, pharmaceutical compounding, women’s health, pain and smoking cessation. Carolyn has won provincial and national awards for her commitment to patient care and public service.

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Looking Back: Raynaud’s Phenomena: More than just C hilly Hands and Feet

This week on our blog, we are continuing our theme of looking back at some of our more popular posts from the last few years. Today, we bring you a very popular one, “Raynauds Phenomenon is more than cold hands and feet.”

Here is the original text:

In our cold winter weather, many people complain of cold hands and feet with reduced circulation to these areas.  Often the skin will be whiter than normal and quickly normalizes once warmed.  Raynaud’s Phenomenon is a level beyond this whereby blood vessels constrict to a greater extent than normal as a result of cold temperatures or stress. There are three phases to the colour change of the skin. Initially, the restricted blood flood causes the skin surface to feel cold and the skin has a white colour, then the skin turns to a purple-blue colour, followed by a pink or red colour as the blood flow eventually returns.

There are prescription medications which can swallowed to promote blood flow that often cause a lowering of blood pressure.  A variety of prescription ingredients can also be prepared in a prescription cream and applied to the affected areas.  Feel free to ask our pharmacists about these options.  Raynaud’s can exist on its own or happen as a result of a pre-existing autoimmune condition.  Be sure to speak to your physician if you are experiencing the symptoms outlined above.  If severe and not treated, lack of blood flow can result and ulceration and the skin and serious consequences.

Keep tuning in to our blog for more of our favourite blogs. If you have a burning question, get in touch with us!

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How do medications get their names?

We often get questions as to why medications have such long complicated names and people wonder if the names have meaning.

In actual fact, the naming of prescription medications is based on international nomenclature regulations. When a new category of medications is introduced, certain groups of letters will be assigned to represent an aspect of how the medication works. Any other medication that is introduced in that category will have to incorporate that same group of letters within their name. For example, medications ending in “olol,” such as atenolol, bisoprolol and propranolol are all referred to as beta blockers and slow the heart rate. Medications ending in ‘zole” such as omeprazole and pantoprazole are acid lowering medications.

In the family of biologic medications which mimic proteins in the human body, several letter combinations have been assigned to indicate how the biologic works and what type of biologic it is. For example…

  • “Mab” at the end of the name means it mimics a monoclonal antibody, such as adalimumab (Humira)
  • If there is an “xi” included in the name, it means the cell used to produce the biologic is chimeric or mouse based such as; Infliximab or Rituximab
  • When the antibody being mimicked by the biological treatment is humanized in origin then “zu” is included, such as tocilizumab.
  • When a biologic is treating a tumour, “tu” is in the name. Such as tratuzamab.
  • Biologics used to treat bones have “os” such as denosumab (Prolia).

There are many more examples of this. The next time you look at a medication’s name, you’ll realize there is a lot of meaning behind those letters.


 

This blog post was written by Charlton Health specialist pharmacists Vishnu Dyal and Carolyn Whiskin.

 

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Looking back…

For many of us September feels like the start of a new year, even though we are still in 2019. As we reflect back over the last 2 1/2 years we have been writing our Wise Words Wednesdays blog, there are posts that generated great interest that are still quite applicable today. In our next few weeks we will highlight some of the top viewed posts and encourage you to use the search bar on the charltonhealthcare.com website to find answers to many of the common questions we receive from our patients.
As an example, I was recently asked about magnesium supplementation from a patient who is on an acid lowering medication. I knew I had written on the topic. We searched “magnesium” in the search bar on our website’s homepage and voila, here is the post that was displayed. It is still great information and I have added a little more…

#WiseWordsWednesday: Do medications affect nutrition?

See the original blog here.

Some medications can affect the way our nutrients are absorbed from the stomach.  One class of medications known to have this effect are called proton pump inhibitors (PPIs).  These medications lower stomach acid production and are commonly taken with anti-inflammatory medications to reduce stomach irritation.  Many people use these medications to reduce reflux of acid which causes heartburn.

The issue with lowering stomach acid is that some nutrients require acid for absorption.  In the presence of low acid, magnesium, vitamin B12, and iron are all poorly absorbed.  This can have many effects such as low energy, restless legs, and leg cramps.  Our pharmacists can help suggest the best types of supplements to restore these levels.  Whenever possible, supplements that can be dissolved on or under the tongue are preferred over those that must be swallowed, as it allows for direct absorption into the blood stream instead of requiring absorption through the stomach.

Magnesium glycinate or bisglycinate is a form of magnesium that is well absorbed and has less adverse effects in regards to affecting bowel routine.  It is often taken before bed and can promote better sleep quality as well as reduce restless leg syndrome and leg cramps.  Most preparations contain 150-200mg of elemental magnesium per capsule.  Dosing ranges from 1-3 nightly, starting at 1 nightly and increasing as needed as long as there is  bowel tolerance.


Carolyn Whiskin is the Pharmacy Manager for Charlton Health.  Carolyn specializes in the treatment of autoimmune diseases, pharmaceutical compounding, women’s health, pain and smoking cessation. Carolyn has won provincial and national awards for her commitment to patient care and public service.

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Resources For Dietary Advice

We often get questions regarding the best diet for a person with an inflammatory condition.  Although there are foods that carry a greater inflammatory impact, eliminating these foods don’t always make a difference for a person’s inflammatory condition.  The best person to ask about your dietary needs are registered dieticians who are held accountable for their advice by a regulatory college.
EatRight Ontario was a great community resource managed by registered dieticians.  This service answered thousands of questions over the phone and e-mail for 10 years.  As of March 2018 this service was cancelled.  Ontario residents can now call Telehealth to speak a dietitian at no charge at 1-866-797-0000.
UnlockFood.ca is a great resource that is managed by the Dieticians of Canada. The site focuses on expert guidance for everyday eating, including articles, featured topics, and a newsletter. One of the many topics listed on the site is arthritis. It includes food choices and physical activity that can help with arthritis. Recommendations for gout are also included on this site. We encourage you to take some time to look at this great resource.

Carolyn Whiskin is the Pharmacy Manager for Charlton Health.  Carolyn specializes in the treatment of autoimmune diseases, pharmaceutical compounding, women’s health, pain and smoking cessation. Carolyn has won provincial and national awards for her commitment to patient care and public service.

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Can I get my flu shot when I just had a Rituxan Infusion?

Every day we get questions in our infusion clinics. Today’s blog features one of those questions…

Rituximab (Rituxan) is a biologic therapy that depletes a specific type of B cell in the immune system. This B cell is responsible for generating antibodies that will promote long term protection against the virus or bacteria the person is being vaccinated for. When available, any needed vaccines should be given two weeks before receiving rituximab as this is the time needed for a vaccine to be effective. Alternatively, you must wait until 5-6 months after the dose for vaccination, as it can take this long for a person to replace their B cells after a Rituxan infusion.

If you are just getting an infusion now and the flu vaccine for this season is not yet available, then you will need to wait until the New Year (5-6 months from now). This will leave you more vulnerable to the flu until that time. Therefore, ensuring your family members and close contacts receive their flu vaccine is very important. Hand washing is one of our best protections from the spread of infection.


Carolyn Whiskin is the Pharmacy Manager for Charlton Health.  Carolyn specializes in the treatment of autoimmune diseases, pharmaceutical compounding, women’s health, pain and smoking cessation. Carolyn has won provincial and national awards for her commitment to patient care and public service.

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The Importance of Adherence

Many people question taking their medication on a regular basis when their disease is under control.  When medication is working well, it is preventing flares of disease.  Each flare of an autoimmune condition can cause damage which is often irreversible.

Treating a condition well means we prevent it from spreading to more areas of the body.  Our advanced treatments for autoimmune disease control the condition but do not cure it.  Lifelong treatment of some type will be needed to control the disease.  So before you stop a therapy or decide to reduce the dose, speak to your specialist about the importance of  maintenance therapy.  People missing doses during a vacation or not wanting to carry their refrigerated product have often regretted this decision when flaring on their holiday.  We can provide travel notes and ice packs as needed, so always ask your pharmacist how we can help rather than miss doses of medication.  It is important to know that in the event that many doses are missed, your treatment may not be as effective when restarted.

Carolyn Whiskin is the Pharmacy Manager for Charlton Health.  Carolyn specializes in the treatment of autoimmune diseases, pharmaceutical compounding, women’s health, pain and smoking cessation. Carolyn has won provincial and national awards for her commitment to patient care and public service.

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Tips for A Better Infusion

  • Ensure you have eaten a full meal prior to your infusion.
  • Drink plenty of water to be well hydrated. This should begin the night before your infusion.
  • Always bring a current list of medications to each infusion. New medications or a change in your health status must always be reported to your infusion nurse.
  • If you are unwell and are unsure if you should come for your infusion, please call ahead.
  • Wear a loose-fitting shirt. This allows the nurse to easily and properly monitor your vital signs.
  • Bring a blanket and/or sweater.
  • Bring something to help pass time (book, laptop, tablet, handiwork). Ensure you have earphones if listening to music/movie so you can be mindful of others in the clinic.
  • Please refrain from wearing perfume or other fragranced products.
  • If you receive Benadryl or Gravol as a pre-medication, it is the policy of the clinic that you do not drive yourself. Please arrange transportation in advance.
  • Kindly inform us of any allergies.
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